New Mass Spectrometry Solution Simplifies Analysis of Macromolecular Complexes Labmate Online


New Solution Enables Simultaneous Load Detection for Analysis of Previously Unmeasurable Analytes

An innovative mass spectrometry solution from Thermo Fisher Scientific Inc provides proteomics and biopharmaceutical laboratories, working in drug discovery and R&D applications, the ability to clearly decipher complex mixtures of large macromolecules.

The Mode Thermo Scientific Direct Mass Technology increase Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap Mass Spectrometers with charge detection capabilities, allowing direct mass determination of hundreds to thousands of individual ions in a single spectrum. As a result, labs can measure the mass of complex heterogeneous mixtures of multiple charged components, unlocking new and rich insights into next-generation drug proteoforms, biotherapies, and modalities.

“Direct Mass Technology mode combines charge sensing with our precise, high-resolution Orbitrap mass measurements to achieve results unattainable with current ensemble measurement techniques,” said Iain Mylchreest, Vice President, Research and Development, Analytical Instruments, Thermo Fisher Scientific. “By dissolving the barriers of complexity inherent in other approaches, we enable a multitude of investigations that were once firmly out of reach – from resolving heavily modified proteoforms to revealing small changes in large antibody-drug conjugate complexes. , to only cite a few. ”

Neil Kelleher, Director of Northwestern Proteomics & the Chemistry of Life Processes Institute, Northwestern University, said, “The differences seen in moving from traditional mass spectrometry to this game-changing direct mass technology are profound. We have moved from no data or uninterpretable data to rich spectra laying bare the complexity of proteoforms. With such solutions, we no longer need to be overwhelmed by the complexity of the human proteome. This technology clearly shows that ultimately we can create tools that match the complexity and scale of our biology.


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